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Monday, April 20, 2020

Obesity and Infertility

Both obesity and being overweight are increasing worldwide and have detrimental influences on several human body functions including the reproductive health. 

In particular, obese women undergo perturbations of the ‘hypothalamic pituitary ovarian axis’, and frequently suffer of menstrual dysfunction leading to anovulation and infertility. 

Besides the hormone disorders and subfertility that are common in the Polycystic ovary syndrome (PCOS), in obesity the adipocytes act as endocrine organ. The adipose tissue indeed, releases a number of bioactive molecules, namely adipokines, that variably interact with multiple molecular pathways of insulin resistance, inflammation, hypertension, cardiovascular risk, coagulation, and oocyte differentiation and maturation.

 Moreover, endometrial implantation and other reproductive functions are affected in obese women with complications including delayed conceptions, increased miscarriage rate, reduced outcomes in assisted conception treatments like IVF.
*The above extract is picked up from NCBI which is a US Medical Journal published in March 2018*.

Recently major research was undertaken to understand the lifestyle changes that has lead to this epidemic of Obesity and Infertility.

1) Psychological stress for social life and work –  There is a larger incidence of depression and anxiety, which is partially related to the lifestyle and to a number of stressing jobs. Thus, the symptoms related to both depression and anxiety have been reported as more prominent in infertile than in fertile women.

2) Smoking  Although in the absence of defined molecular mechanisms, there is an apparently negative influence of smoking resulting in reduced fertility in female smokers.

3) Drugs, caffeine and alcohol  There are a number of daily or occasionally assumed drugs that are known to impact fertility. Non-steroidal anti-inflammatory drugs, commonly used to treat pain or inflammation are defined ovulation inhibitors.
On the other hand, higher introduction of caffeine has been associated with an increased risk of pregnancy loss, whereas in alcohol abusers the liver metabolic alterations and/or psyconeurologic damages concur with stress factors to restrain the oocyte maturation.

4)Diet and variations of body weight – Inadequate diets as those with inadequate protein content, based on habitual hypercaloric food assumption, leading to overweight, definitely affect the ovarian function and increase the risk of women infertility.

5) Sedentary Lifestyle or reduced physical activity leads to reduced oxygenation of the tissues and accumulation of toxins leading to reduced normal functioning of all body organs including the reproductive system.

Obesity is defined as an abnormal accumulation of body fat, usually 20% or more over an individual's ideal body weight.This is often described as a body mass index (BMI) over 30.
Obesity is usually the result of consuming more calories than the body needs and not expending that energy by doing exercise.People in the obese category are much more likely to suffer from infertility problems than people of normal healthy weight.

A report carried out by the Nurses Health Study demonstrated an increased risk of anovulation in women with an increasing BMI value.Its major effects include a reduction in ovulation rate, a decline in oocyte quality, menstrual irregularities, a decreased pregnancy rate and a rise in miscarriages.

In my personal experience, My wife Yogita Satpute had first pregnancy at age of 27, 3 years after marriage. She had weight gain of 15 kg after her first pregnancy. When we tried for second child when she was 32, we had problems namely irregularities in ovulation and miscarriage. This went for 2 years.  
Doctors suggest us atleast 10kg weightloss.  Weightloss with varies option was not fruitful. 
Then Thanks to Vrindavan Nutrition, under guidance of Dr. Hitesh and Dr. Neelima, my wife lost 12 kgs in just 4 months.

Result: Her pregnancy test came positive in the the following month, making us more happy than ever before.
  So with above medical studies and our personal experience it can be concluded firmly that obesity and infertility go hand in hand.

I would also like to add that most of the men think than only women are responsible for not conceiving a child.
Well, i have bad news for all such men.
All the above mentioned risk factors reduce the morphology and normal count of sperms.
In a lot of instances, the woman is ovulating absolutely normal, but because of the abnormal morphology of sperms, the embryo that is formed is not of acceptable grade, leading to non conception or early miscarriage.

Conception is a Team Work. 
Knowledge,Support and Care are the true elements required for definite results.

   Written By:

              Dr Satchidanand R Satpute
                             Wellness Coach